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MMP2 (Cat #: AA123)
Rabbit polyclonal antibody to MMP2
MMP2 in prostate cancerImmunohistochemical detection of MMP2 in formalin fixed human prostate cancer. 10 μm paraffin-embedded tissue sections were incubated with rabbit polyclonal antibody to MMP2 at 6 μg/mL overnight at 4°C followed by HRP/AEC detection (red) and counterstaining with hematoxylin (blue). Function: Metalloproteinase 2 is a 72kDa enzyme involved in remodeling of the vasculature, invasion of tumors and degrading extracellular matrix proteins. Its C-terminal does not have a catalytic function and have anti-tumor activity. Cane be detected extracellularly, in cytoplasm and cell nuclei. MMP2 is present in many tumors including breast and prostate cancer.
Formulation Lyophilized powder
Purification Affinity purified
Host Species Rabbit
Unit Size: 100 µg
Immunogen Synthetic peptide
Alternative Names 72 kDa gelatinase, Gelatinase A
Accession Number: P08253
Gene Symbol MMP2
Accession URL:
Applications: Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blotting (WB).
Working Dilution for Immunofluorescence (ICC): 5 – 15 µg/mL
Working Dilution for Immunohistochemistry (IHC): 5 – 10 µg/mL
Working Dilution for Western Blottin (WB): 1 µg/mL
IHC Positive control: Tumors of different origin
Specificity: Confirmed by WB.
Reactivity: Human
Reconstitution: Reconstitute in 0.05 mL of PBS (pH 7.4) to achieve an antibody concentration of 1000 µg/mL. Centrifuge to remove any insoluble material.
Storage / Stability: At least 12 months after purchase at 2 - 4°C. After reconstitution, aliquot and store at -20°C for a higher stability and at 4°C with an appropriate antibacterial agent. Avoid freeze-thaw cycles.
  1. Qian Q, Wang Q, Zhan P, Peng L, Wei SZ, Shi Y, Song Y. Cancer Invest. 2010 Jul;28(6):661-9. Review. PMID: 20394501.
  2. Sounni NE, Janssen M, Foidart JM, Noel A. Matrix Biol. 2003 Mar;22(1):55-61. Review. PMID: 12714042.
  3. Fillmore HL, VanMeter TE, Broaddus WC. J Neurooncol. 2001 Jun;53(2):187-202. Review. PMID: 11716070.
  4. Bramhall SR, Neoptolemos JP, Stamp GW, Lemoine NR. J Pathol. 1997 Jul;182(3):347-55. PMID: 9349239.

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